ABSTRACT
Sodium carboxymethyl cellulose is an excellent pharmaceutical excipient. It possesses good filmability, mucoadhesiv-ity, viscolising capacity and bindability. The current aim of our research work is to synthesize a novel colon targeting polymer by using sodium carboxymethyl cellulose and glycine for colon targeting and to screen its colon specificity by in-vitro release model. Sodium carboxymethyl cellulose was subjected for synthesizing its derivative with glycine using azo linkage. The azo polymeric conjugate was evaluated for its color, solubility, Rf value, melting point, IR and 1HNMR spectral analysis. It was further subjected for evaluating its colon targeting property by in-vitro method using rat fecal matter. The research study revealed that the sodium carboxymethyl cellulose azo derivative showed promising colon specificity for a period of 120 minutes in a controlled manner along with modified solubility. So it can serve as a potential colon targeting polymer.
ABSTRACT
Sodium carboxymethyl cellulose is an excellent pharmaceutical excipient. It possesses good filmability, mucoadhesiv-ity, viscolising capacity and bindability. The current aim of our research work is to synthesize a novel colon targeting polymer by using sodium carboxymethyl cellulose and glycine for colon targeting and to screen its colon specificity by in-vitro release model. Sodium carboxymethyl cellulose was subjected for synthesizing its derivative with glycine using azo linkage. The azo polymeric conjugate was evaluated for its color, solubility, Rf value, melting point, IR and 1HNMR spectral analysis. It was further subjected for evaluating its colon targeting property by in-vitro method using rat fecal matter. The research study revealed that the sodium carboxymethyl cellulose azo derivative showed promising colon specificity for a period of 120 minutes in a controlled manner along with modified solubility. So it can serve as a potential colon targeting polymer.
ABSTRACT
Phoenix dactylifera belongs to the family Arecaceae. The current aim of our research work is to isolate bio-material from the fruit pulp of Phoenix dactylifera and evaluate its mucoadhesivity. The bio- material was isolated by simple economical process. The isolated biomaterial was subjected for determination of solubility, colour changing point, viscosity, surface tension, pH and chemical tests. The mucoadhesivity of the biomaterial was assessed by shear stress method and rotating cylinder method using Capra aegagrus labium and intestine as mucosal substrates. The results were compared with HPMC and sodium CMC. The research study revealed that the biomaterial from Phoenix dactylifera exhibits promising inbuilt mucoadhesivity. So it can serve as a powerful natural mucoadhesant and may be used to develop mucoadhesive transmucosal drug delivery systems.
ABSTRACT
The aim of our research work was to isolate a novel bio-material from unripe fruit pulp of Artocaropus heterophyllus, and to evaluate its bio-emulsifying ability by formulating escitalopram emulsions. The bio-material was isolated from the unripe fruit pulp of Artocarpus heterophyllus by simplified economic process. It was subjected for various physicochemical parameters like color, colour changing point, chemical tests, IR spectral study. Four Drug loaded emulsions were formulated(AH1-AH4) using varying ratios of the bio-material. The emulsions were formulated using Escitalopram as a model drug. The formulated emulsions were subjected for evaluation parameters like globule size, pH, effect of centrifugation, viscosity, surface tension, creaming, freezing and thawing cycles and in-vitro release. The infra red spectra of the bio-material showed the presence of saturated hydrocarbons, aromatic ring and secondary and tertiary alcohol groups. The emulsions showed a globule size in the range 0.15-0.17μm, viscosity of 11.4±0.5cp to 17.6±1.2cp, surface tension in the range 59.67±1.3 to 65.42±1.45 dyne/cm. The emulsions had content uniformity of 73%±2.1% to 81%±1.85%. The in-vitro drug release studies from the formulated emulsions exhibited a controlled release for a period of 8 hours. The formulation AH3 was found to be best formulation on the basis of evaluation parameters, in-vitro release study and stability study. It showed content uniformity of 77% and was found to be stable with no signs of phase separation, creaming and showed controlled release of more than 8 hours with t80% of more than 5.5 hours. The emulsions followed zero order release as shown by the higuchi model. The release curves were fitted to korsenmeyer equation and showed linear release profile.